Comparison of anthro-metabolic indicators for predicting the risk of metabolic syndrome in the elderly population: Bushehr Elderly Health (BEH) program

Rabiei, N. and Heshmat, R. and Gharibzadeh, S. and Ostovar, A. and Maleki, V. and Sadeghian, M. and Maleki Birjandi, S. and Nabipour, I. and Shafiee, G. and Larijani, B. (2021) Comparison of anthro-metabolic indicators for predicting the risk of metabolic syndrome in the elderly population: Bushehr Elderly Health (BEH) program. Journal of Diabetes and Metabolic Disorders. ISSN 22516581 (In Press)

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Abstract

Background Metabolic syndrome (MetS) is a cluster metabolic disorder that includes central obesity, insulin resistance, hypertension, and dyslipidemia, and is highly associated with an increased risk of developing non-communicable diseases (NCDs). This study aimed to compare the reliability of anthro-metabolic indices [visceral adiposity index (VAI), body roundness index (BRI), and a body shape index (BSI), body adiposity index (BAI), lipid accumulation product (LAP), waist to hip ratio, and waist to height ratio] in predicting MetS in Iranian older people. Methods This cross-sectional study was conducted based on the data of 2426 adults aged ≥60 years that participated in the second stage of the Bushehr Elderly Health (BEH) program, a population-based prospective cohort study being conducted in Bushehr, Iran. MetS was defined based on the revised National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria. The receiver operating characteristic (ROC) curve analysis was used to assess predictive performance of anthro-metabolic indices and determine optimal cutoff values. Logistic regression analysis was applied to determine the associations between MetS and indices. Results 2426 subjects (48.1% men) with mean ± SD age of 69.34 ± 6.40 years were included in the study. According to ATP III criteria, 34.8% of men and 65.2% of women had MetS (P < 0.001). Of the seven examined indices, the AUCs of VAI and LAP in both genders were higher than AUCs of other anthro-metabolic indices. Also, in general population, VAI and LAP had the greatest predictive power for MetS with AUC 0.87(0.86–0.89) and 0.87(0.85–0.88), respectively. The lowest AUC in total population belonged to BSI with the area under the curve of 0.60(0.58–0.62). After adjusting for potential confounders (e.g. age, sex, education, physical activity, current smoking) in the logistic regression model, the highest OR in the total population was observed for VAI and LAP, which was 16.63 (13.31–20.79) and 12.56 (10.23–15.43) respectively. The lowest OR for MetS was 1.93(1.61–2.30) for BSI. Conclusion This study indicated that both VAI and LAP are the most valuable indices among the anthro-metabolic indices to identify MetS among the elderly in both genders. So, they could be used as proper assessment tools for MetS in clinical practice. However, the cost-benefit of these indices compared to the ATP III criteria need further studies.

Item Type:	Article
Uncontrolled Keywords:	Metabolic syndrome · Anthro-metabolic indices · Older adults · Prediction value
Subjects:	WT Geriatrics . Chronic Diseases
Divisions:	Research Center > The Persian Gulf Tropical Medicine Research Center
Depositing User:	خدیجه شبانکاره
Date Deposited:	27 Dec 2021 09:59
Last Modified:	27 Dec 2021 09:59
URI:	http://eprints.bpums.ac.ir/id/eprint/9463

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