Assadi, M. and Rekabpour, S.J. and Jafari, E. and Divband, G. and Nikkholgh, B. and Amini, H. and Kamali, H. and Ebrahimi, S. and Shakibazad, N. and Jokar, N and Nabipour, I. and Ahmadzadehfar, H. (2021) Feasibility and Therapeutic Potential of 177Lu-Fibroblast Activation Protein Inhibitor-46 for Patients With Relapsed or Refractory Cancers: A Preliminary Study. Clinical nuclear medicine, 46 (11). e523-e530. ISSN 15360229
Full text not available from this repository.Abstract
INTRODUCTION: Fibroblast activation protein (FAP) is a member of the serine protease family and has a high expression in the stroma of approximately 90% of epithelial malignancies. The present investigation aimed to assess the feasibility, safety, and dosimetry data of 177Lu-FAPI-46 in diverse malignancies. PATIENTS AND METHODS: Patients with advanced cancers with nonoperable tumors, or tumors refractory to conventional therapies, were enrolled. Treatment included escalating doses of 177Lu-FAPI-46 (1.85-4.44 GBq) per cycle using a combination of clinical and statistical expertise design, and intervals of 4 to 6 weeks were considered between the cycles. Biodistribution and dosimetry were examined by whole-body scans. We applied the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.03 to measure peptide-targeted radionuclide therapy (PTRT)-associated toxicity. RESULTS: A total of 21 patients (11 females and 10 males) with a median age of 50 years (range, 6-79 years) were investigated. Of 21 participants, 18 cases were selected for PTRT. Overall, 36 PTRT cycles were performed. The median number of PTRT cycles and the median injected amount of activity in each cycle were 2 and 3.7 GBq, respectively. The dosimetric analysis revealed median absorbed doses of 0.026, 0.136, 0.886, and 0.02 with ranges of 0.023-0.034, 0.001-0.2, 0.076-1.39, and 0.002-0.2 mGy/MBq for the whole body, liver, kidneys, and spleen, respectively. The therapy was well tolerated in almost all patients. CONCLUSIONS: The findings of this preliminary investigation might indicate the potential feasibility and safety of PTRT using 177Lu-FAPI-46 for different aggressive tumors. Moreover, the current study could be beneficial in determining the suitable amount of activity for a phase 2 study.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Adolescent; Adult; Aged; Child; Feasibility Studies; Female; Fibroblasts; Humans; Male; Middle Aged; Neoplasms; Quinolines; Radioisotopes; Tissue Distribution; Young Adult |
| Subjects: | WN Radiology . Diagnostic Imaging |
| Divisions: | Research Center > Persian Gulf Nuclear Medicine Research Center |
| Depositing User: | خدیجه شبانکاره |
| Date Deposited: | 27 Dec 2021 09:55 |
| Last Modified: | 27 Dec 2021 09:55 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/9480 |
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