Oncogenic osteomalacia secondary to glomus tumor

Raj, R and Hasanzadeh, S and Dashtizadeh, M and Kalantarhormozi, M and Vahdat, K and Dabbaghmanesh M, H and Nabipour, I and Ravanbod, M and Assadi, M and Hashemi, B and Asadipooya, K (2021) Oncogenic osteomalacia secondary to glomus tumor. Endocrinology, Diabetes and Metabolism Case Reports, 2021 (1). ISSN 2052-0573

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Oncogenic osteomalacia secondary to glomus tumor is extremely rare. Localization of causative tumors is critical as surgical resection can lead to a complete biochemical and clinical cure. We present a case of oncogenic osteomalacia treated with resection of glomus tumor. A 39-year-old woman with a history of chronic sinusitis presented with chronic body ache and muscle weakness. Biochemical evaluation revealed elevated alkaline phosphatase hypophosphatemia, increased urinary phosphate excretion, low calcitriol, and FGF23 was unsuppressed suggestive of oncogenic osteomalacia. Diagnostic studies showed increase uptake in multiple bones. Localization with MRI of paranasal sinuses revealed a sinonasal mass with concurrent uptake in the same area on the octreotide scan. Surgical resection of the sinonasal mass was consistent with the glomus tumor. The patient improved both clinically and biochemically postoperatively. Along with the case of oncogenic osteomalacia secondary to a glomus tumor, we have also discussed in detail the recent development in the diagnosis and management of oncogenic osteomalacia. Learning points: •• Tumor-induced osteomalacia is a rare cause of osteomalacia caused by the secretion of FGF23 from mesenchymal tumors. •• Mesenchymal tumors causing TIO are often difficult to localize and treat. •• Resection of the tumor can result in complete resolution of biochemical and clinical manifestations in a very short span of time. •• Glomus tumor can lead to tumor induced osteomalacia and should be surgically treated.

Item Type: Article
Uncontrolled Keywords: Adult; Female; Other; Iran, Islamic Republic of; Bone; Bone; General practice; Nephrology; Oncology; Radiology/Rheumatology; Otolaryngology; New disease or syndrome: presentations/diagnosis/management
Subjects: R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicin
Depositing User: خدیجه شبانکاره
Date Deposited: 27 Dec 2021 09:55
Last Modified: 27 Dec 2021 09:55
URI: http://eprints.bpums.ac.ir/id/eprint/9488

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