Shooli, H and , Nemati, R and Chabi, N and Larvie, M and , Jokar, N and , Dadgar, H and Gholamrezanezhad, A and Assadi, M (2021) Multimodal assessment of regional gray matter integrity in early relapsing-remitting multiple sclerosis patients with normal cognition: A voxel-based structural and perfusion approach. British Journal of Radiology, 94 (1127). ISSN 0007-1285
Full text not available from this repository.Abstract
Objective: There is increasing evidence that gray matter (GM) impairment is strongly associated with clinical performance decline. We aim to perform a voxelwise analysis between regional GM (rGM) perfusion and structural abnormalities in early relapsing-remitting multiple sclerosis patients with normal cognition (RRMS-IC) and explore clinical correlate of early rGM abnormalities. Methods and materials: We studied 14 early RRMS-IC patients and 14 healthy age- and sex-matched controls. Brain perfusion single photon emission computed tomography (SPECT), structural MRI, and a comprehensive neuropsychological examination were acquired from all participants. Neuropsychological tests include expanded disability status scale, minimal mental status examination, short physical performance battery, Wechsler memory scale, and quick smell test. Voxelbased morphometry was used for analyzing SPECT and T1-MR images to identify rGM hypoperfusion and atrophy, respectively (RRMS-IC vs controls (group analysis), and also, each patient vs controls (individual analysis)) (p [removed] 0.05). rGM abnormalities correlated with several relevant minimal clinical deficits. Conclusion: Lack of spatial correlation between rGM atrophy and hypoperfusion might suggest that independent mechanisms might underlie atrophy and hypoperfusion. Perfusion SPECT may provide supplementary information along with MRI. Advances in knowledge: Association between rGM atrophy and rGM hypoperfusion and their clinical significance in early RRMS-IC is not well described yet. Our study showed that there is spatial dissociation between rGM atrophy and rGM hypoperfusion, suggesting that different mechanisms might underlie these pathologies.
| Item Type: | Article |
|---|---|
| Subjects: | WT Geriatrics . Chronic Diseases |
| Divisions: | Research Center > Persian Gulf Nuclear Medicine Research Center |
| Depositing User: | خدیجه شبانکاره |
| Date Deposited: | 27 Dec 2021 09:52 |
| Last Modified: | 27 Dec 2021 09:52 |
| URI: | http://eprints.bpums.ac.ir/id/eprint/9493 |
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