Mesenchymal stromal/stem cells and their exosomes for restoration of spermatogenesis in non-obstructive azoospermia: a systemic review

Zhankina, R and Baghban, N and Askarov, M and Saipiyeva, D and Ibragimov, A and Kadirova, B and Khoradmehr, A and Nabipour, I and Shirazi, R and Zhanbyrbekuly, U and Tamadon, A (2021) Mesenchymal stromal/stem cells and their exosomes for restoration of spermatogenesis in non-obstructive azoospermia: a systemic review. Stem Cell Research and Therapy, 12 (1). ISSN 17576512

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Official URL: https://stemcellres.biomedcentral.com/articles/10....

Abstract

Stem cells have been introduced as new promising therapeutic agents in treatment of degenerative diseases because of having high differentiation potential while maintaining the ability to self-replicate and retaining features of their source cells. Among different type of cell therapies, mesenchymal stromal/stem cell (MSC) therapy is being increasingly developed as a new way to treat structural defects that need to be repaired and regenerated. Non-obstructive azoospermia (NOA) is a reproductive disease in men that causes infertility in 10% of infertile men. Based on in vitro studies, MSCs from different tissue sources have been differentiated into germ cells or gamete progenitor cells by simple methods in both male and female. On the other hand, the therapeutic effects of MSCs have been evaluated for the treatment of NOA animal models created by chemical or surgical compounds. The results of these studies confirmed successful allotransplantation or xenotransplantation of MSCs in the seminiferous tubules. As well, it has been reported that exosomes secreted by MSCs are able to induce the process of spermatogenesis in the testes of infertile animal models. Despite numerous advances in the treatment of reproductive diseases in men and women with the help of MSCs or their exosomes, no clinical trial has been terminated on the treatment of NOA. This systematic review attempts to investigate the possibility of MSC therapy for NOA in men

Item Type: Article
Uncontrolled Keywords: Animal model; Clinical trial; In vitro study; Infertility; Mesenchymal stromal/stem cell; Non-obstructive azoospermia
Subjects: WE Musculoskeletal system
Divisions: Research Center > Persian Gulf Marine Biotechnology Research Center
Depositing User: خدیجه شبانکاره
Date Deposited: 27 Dec 2021 08:31
Last Modified: 27 Dec 2021 08:31
URI: http://eprints.bpums.ac.ir/id/eprint/9502

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