Association of amino acid metabolites with osteoporosis, a metabolomic approach: Bushehr elderly health program

Panahi, Nekoo and Fahimfar, Noushin and Roshani, Shahin and Arjmand, Babak and Gharibzadeh, Safoora and Shafiee, Gita and Migliavacca, Eugenia and Breuille, Denis and Feige, Jerome N. and Grzywinski, Yohan and Corthesy, John and Razi, Farideh and Heshmat, Ramin and Nabipour, Iraj and Farzadfar, Farshad and Soltani, Akbar and Larijani, Bagher and Ostovar, Afshin (2022) Association of amino acid metabolites with osteoporosis, a metabolomic approach: Bushehr elderly health program. Metabolomics, 18 (8). ISSN 1573-3882

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Amino acids are the most frequently reported metabolites associated with low bone mineral density (BMD) in metabolomics studies. We aimed to evaluate the association between amino acid metabolic profile and bone indices in the elderly population. Methods 400 individuals were randomly selected from 2384 elderly men and women over 60 years participating in the second stage of the Bushehr elderly health (BEH) program, a population-based prospective cohort study that is being conducted in Bushehr, a southern province of Iran. Frozen plasma samples were used to measure 29 amino acid and derivatives metabolites using the UPLC-MS/MS-based targeted metabolomics platform. We conducted Elastic net regression analysis to detect the metabolites associated with BMD of different sites and lumbar spine trabecular bone score, and also to examine the ability of the measured metabolites to differentiate osteoporosis. Results We adjusted the analysis for possible confounders (age, BMI, diabetes, smoking, physical activity, vitamin D level, and sex). Valine, leucine, isoleucine, and alanine in women and tryptophan in men were the most important amino acids inversely associated with osteoporosis (OR range from 0.77 to 0.89). Sarcosine, followed by tyrosine, asparagine, alpha aminobutyric acid, and ADMA in women and glutamine in men and when both women and men were considered together were the most discriminating amino acids detected in individuals with osteoporosis (OR range from 1.15 to 1.31). Conclusion We found several amino acid metabolites associated with possible bone status in elderly individuals. Further studies are required to evaluate the utility of these metabolites as clinical biomarkers for osteoporosis prediction and their effect on bone health as dietary supplements.

Item Type: Article
Subjects: WB Practice of Medicine
Divisions: Faculty of Medicin > Department of Infectious Diseases
Depositing User: خدیجه شبانکاره
Date Deposited: 11 Oct 2022 11:02
Last Modified: 11 Oct 2022 11:02

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