The role of SF3B1 and NOTCH1 in the pathogenesis of leukemia

Abolhasani, Shiva and Hejazian, Seyyed Sina and Karpisheh, Vahid and Khodakarami, Atefeh and Mohammadi, Hamed and Gholizadeh Navashenaq, Jamshid and Hojjat-Farsangi, Mohammad and Jadidi-Niaragh, Farhad (2022) The role of SF3B1 and NOTCH1 in the pathogenesis of leukemia. IUBMB Life. ISSN 1521-6543

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The discovery of new genes/pathways improves our knowledge of cancer pathogenesis and presents novel potential therapeutic options. For instance, splicing factor 3b subunit 1 (SF3B1) and NOTCH1 genetic alterations have been identified at a high frequency in hematological malignancies, such as leukemia, and may be related to the prognosis of involved patients because they change the nature of malignancies in different ways like mediating therapeutic resistance; therefore, studying these gene/pathways is essential. This review aims to discuss SF3B1 and NOTCH1 roles in the pathogenesis of various types of leukemia and the therapeutic potential of targeting these genes or their mutations to provide a foundation for leukemia treatment.

Item Type: Article
Subjects: QW Microbiology and Immunology
Divisions: Faculty of Medicin > Department of Immunology and Allergy
Depositing User: خدیجه شبانکاره
Date Deposited: 11 Oct 2022 10:36
Last Modified: 11 Oct 2022 10:36

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