Bone mass and microarchitecture in T2DM patients and corticosteroids therapy: the Bushehr Elderly Health program

Gharibzadeh, Safoora and Goodarzi, Golnaz and Samavarchi Tehrani, Sadra and Fahimfar, Noushin and Razi, Farideh and Sanjari, Mahnaz and Khalagi, Kazem and Shafiee, Gita and Heshmat, Ramin and Amini, Azam and Nabipour, Iraj and Larijani, Bagher and Ostovar, Afshin (2022) Bone mass and microarchitecture in T2DM patients and corticosteroids therapy: the Bushehr Elderly Health program. Journal of Diabetes & Metabolic Disorders, 21. pp. 717-125. ISSN 2251-6581

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Purpose Our study examined whether T2DM and glucocorticoids treatment affect bone quality and quantity that are measured by Bone Mineral Density (BMD) and Trabecular Bone Score (TBS). Materials & methods Participants in this study were 2294 women and men aged over 60 years who participated in stage II of the Bushehr Elderly Health (BEH) program. Patients with T2DM and those who received glucocorticoids were included. BMD was detected using the DXA method and the TBS of L1-L4 was evaluated by TBS iNsight® software. To evaluate the correlation between TBS and BMD levels with diabetes and taking corticosteroids sex-specific multivariable linear regression models were appplied. Results TBS and BMD were not significantly different in those who had received glucocorticoids versus those who did not.T2DM revealed a significant association with both BMD and TBS in men (beta = 0.12, p < 0.001 and beta = 0.063, p = 0.03, respectively). BMD values were significantly higher in diabetic women (beta = 0.073, p < 0.01). BMI had a significant association with both TBS and BMD but in an opposite direction, in women and men (BMD: beta = -0.22, -0.24, and regarding TBS: beta = 0.37, 0.25, all p-values < 0.001). Conclusion Our findings showed that T2DM had major effects on BMD in both men and women. However, T2DM only affects TBS in men. Furthermore, neither BMD nor TBS were affected by GC intake in men or women.Based on the variable importance of covariates, BMI was the most influential factor on both BMD and TBS, although in opposite directions, in both sexes.

Item Type: Article
Subjects: WB Practice of Medicine
Divisions: Faculty of Medicin > Department of Internal Medicine
Depositing User: خدیجه شبانکاره
Date Deposited: 22 Oct 2022 06:24
Last Modified: 22 Oct 2022 06:24

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